S.R.
The only thing that is clinically proven to actually reduce wrinkles (not just the appearance of wrinkles) is Retin A which makes the upper layers peel and stimulates collagen. It is available by prescription, but I think you can get it from reputable on-line pharmacies as well. I have used it for years, and I think my skin has done very well (but you have to use sunsceen with it)