H.U.
Second Hand Rose in downtown Mt. Clemens donates toys/clothes, etc to the families in their shelters. Usually domestic violence families. The items they don't take to the shelter goes up for sale in their resale shop, and all the money benefits the domestic violence shelter as well.
Also, you can donate just about anything in your home to Salvation Army (several in Macomb County), or any of the Thrift shops up on the north west corner of 16 Mile & Gratiot.
Just pull up and drop them off!