C.O.
No. It would not bother me in the least.
I don't think she will be rough-housed or bullied - most girls will end up taking control and being the bully to the boys - sorry - but in working in daycare that has been my experience when a girl if outnumbered - especially one who is strong - she will just come in and take control...
There's NOTHING wrong with a girl playing with boys...seriously...she may learn something!!!! :)