This is an honest question and not a criticism -- have you directly asked anyone for specific help? You mention that "family has never asked if they could be of any assistance" but did you, yourself, ever approach them to ask them to be of assistance, ask for them to come to place X at time Y to do thing Z? I do not mean the question to come off as critical. I really do want to know if your asking was part of the equation at some point, because if it wasn't, they might be assuming you don't need or want help.
If you did ask and were turned down, you did the right thing by being specific and asking, and now you know not to try again, at least. If you did not ask, they can't know they're needed unless you do. But honestly, from what you post, I wonder if you would want them, especially your mom, around you much anyway, IF they even said yes.
You do have a lot of pain here regarding your mother's distant relationship with you, and that relationship is your clear sign that she's just not going to step up or volunteer or make offers -- it would be out of character and her character's been clear since you were a kid, sadly. As B. posted below, you want your family to be people they just aren't. Sometimes we all do. But instead of expending your precious mental energy being angry at them or at God, take that energy and do something about finally sloughing off your past and your present disappointment.
I really hope you will see a therapist, if you haven't already, to work on and get past your last sentence in the post. No one should go through their life feeling this bad. But you don't have to navigate it all alone. There is a lot of help out there to put your childhood and your current relationships (like with your husband's siblings) into perspective instead of letting it control you and create false hopes, like the hope that people will make offers they will never make. Therapy can also show you how people are not going to change because we hope they will, or because we have a major life change (like kids)..
As for the in-laws, I say, in-laws are the business of their adult child, in this case, your husband. If you need help, he has to step up and ask them for it. If they can't or won't, that's their prerogative, frankly. How you and your husband feel about it is another thing. You can stay angry and hurt or learn to let it go and stop wanting them, and your mom, to become involved grandparents, aunts and uncles, since that is not in their personalities or in their desires. Again, a good therapist or counselor can help you find some peace with that.
One aside: Those 20-something siblings of your husband's could end up being terrific aunts and uncles once they're a bit older, especially if right now they are in various stages of focusing on their careers, getting married or pretty newly married, or starting families, etc. Their life stage may be very different from yours at this time but in a few years, they may be at a place where they are settled in and more understanding of, and interested in, their brother's kids. So please don't write them off. You mention: "I guess that they are 'too busy' or immature to step up to the plate" -- but again, did they know there was a plate to step up to, or that you wanted help from them? They might even have figured that you'd ask the in-laws/your mom first before them and since they didn't hear from you they didn't want to bug you, or didn't know what to offer you if they don't have kids and don't really understand what's involved. So consider giving them a break, and reaching out to them and not waiting for them to reach out to you.
Happened with us. My brother has become a really great uncle (and better brother) in recent years. He just needed to hit the right place in his life to understand some things. If I'd written him off earlier, I wouldn't know this person he is today, and neither would our daughter. Just a thought.