Don't know if you mean Disney World in Florida or Disneyland in California - so this applies to Disney World.
We have stayed at Boardwalk, Beach Club, Port Orleans, Carribean beach, and Animal Kingdom Lodge. (I used to go to a conference every January there and it was paid for!) We LOVED the Animcal Kingdom Lodge. Every morning was like looking out the window at a zoo, they have special African programs in the lobby, and the food was very tasty.
Port Orleans and Carribean Beach were very similar - Carribean Beach had better pools. Boardwalk and Beach Club both sit by a "lake" and you can shuttle to Epcot via boat. (Same with Port Orleans.) Boardwalk had a better room, but Beach Club had better pools.
It really depends on how much you want to spend. We found the kids love the parks, love the pools, and really don't care about the room -- one thing we always do, though, is pay the upcharge for a refridgerator and do a liitle grocery shopping. We get cereal, milk, chips, bread, sandwich fixings, etc. and we only ate dinner out, which saved a bunch. Coming back to the room each day for lunch and a little pool time also made the trip a lot less hectic.
Have fun!