Social Skills: Benadryl

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Benadryl for Travel?

This may sound awful so I am asking for some feedback on this subject. I have a very wiggly 14 month old who can not sit still for 1 minute and we are going on a four hour flight mid day. I was told by some friends that benadryl has been a life saver on some flights. Does anyone have any positive or negative experience with this? Please do not post any judgements if you haven't done this yourself. Thanks!