T.K.
Make sure what ever "comforts" your child is present in the Room. My now 3 1/2 year old has not only had a new bedroom, but a new house 2 times now and is going to have a third new house this summer (Military) - we just make sure the things he finds comforting are among the first things we unpack when we get to our new house ( some of them travel with us - favorite blanket/stuffed animal, maybe one toy). Kids are pretty resilient - the adjust pretty quickly.
My two older boys still have their favorite blankets and stuffed animals that they like to have in their room - or in the car - or at least in the house they are in. They may not pull them out of the suitcase, but we never travel without those things.
Good Luck!
T.