I got pregnant with my second son about 5 months after going off the shot, the first time. BUT I also reacted totally different from anyone that I have ever talked to. My bodies reaction was to make it where I couldn't gain weight for nothing. I dropped down to 110 after my first son was born (yeah i know I reacted to pregnancy different than others too lol), I never had any periods while on it, and had no hormonal problems. In fact that was how I knew when to go off of the shot lol. When my younger son was around 4 I all the sudden started gettting every side effect that came with the shot, and so I went off of it. I haven't gotten pregnant since going off of it this time though, and it's been about 3 years. (but I don't want anymore kids either, so that is a good thing for me)