I have been on everything, Proactive, Murad, retin-a, even on Accutane when I was a teen! Prescribed oral pills work best for me, but can't take those while pregnant or nursing.
I recently found this, and it works best out of all the over the counter acne creams ever, my face is actually pretty clear right now, and it reduces the size and redness of breakouts really fast, especially the painful ones. (I've only been using it for about 2 weeks, but noticed results right away).
I read the back, 10% benzoyl peroxide.. that is a lot compared to other creams that had maybe only 2%.
It's only about a $6 tube at the grocery store and it's awesome! Doesn't dry out my skin, doesn't bleach my clothes (that I've noticed anyways) doesn't get all flaky or cakey.
I just put it on 2 times a day, in the morning after washing my face and at night after washing my face, I put on a little bit on my bad areas and rub it in really good.
It's called AcneFree Acne & Blackhead Terminator 10, Time-Released 10% Benzoyl Peroxide. It's in an orange and white box, and an orange tube.
This is what it looks like and reviews:
http://www.buzzillions.com/reviews/acnefree-university-me...
There is also a baking soda mask and a salt treatment that works well too, if you want to try something all natural, but they are kind of messy, so it works well in the mornings or nighttime:
salt (read the comments, there are some tips in there):
http://www.cutoutandkeep.net/projects/best_pimple_killer_...
baking soda mask:
http://www.acne.org/baking-soda-reviews/209/page1.html
Just be sure to wash your face with a mild cleanser and lid water, not scrub or pick at the acne and drink lots of water.