D.W.
We're in the same situation.
I grew-up outside Washington, D.C., my husband is from the Cleveland area. We live outside Indianapolis.
There are times it's tough not having family around, but it's the life we chose, and with the economy the way it is, it's not going to change any time soon. So, like other people recommended, Skype and phone calls are great.
I'm a little different from other new moms, though. When we had our first child almost 4 years ago, I didn't want people to come and help me for a week or two. The reason is that my reality was being on our own without having grandparents to drop kids off with so we can have a nice evening or a weekend to ourselves. I made all my own meals as soon as we got home, did all my own shopping/laundry so I knew how hard it was going to be without a false sense of hope. Everyone is different - that's just how I needed to do it.
When I was diagnosed with cancer following my second child's birth, that reality really hit close to home. My husband had to assume many more responsibilities during my treatment (my diagnosis was the day before our son's 2nd birthday, our daughter was 10.5 weeks old). But, we survived without relying on our families.
If you accept your life as it is, it makes it much better to get through day-to-day. Parenthood will strengthen some relationships and ruin others. You'll make many new friends as your kids age and interact.
Your children will build the bond with your family if you make it a priority. Keep pictures around, talk about your family often, and use modern technology to let them know who is important to you.