I didn't bother with prescribed antibiotics when my child had an ear infection. Garlic oil droplets (made specifically for ear infections) and colloidal silver worked just as good (drops in ear) plus cleaned the ear w/drops of peroxide and let it fizzle (through in their favorite movie while doing this). Did this daily and alternated between garlic and silver, but nightly cleanings with peroxide. If it's antibiotics that are dropped in the ear, you're fine giving probiotics anytime. If it's antibiotics by mouth, give probiotics in between. If you give anti and pro via mouth at the same time, you're killing the pro with the anti!