Please don't... if they wake up they could get into just anout anything before you could get in the house.
I sometimes think my daughter will sleep for awhile - exhausted and just went down for her nap- and so I will start a messy acitivty (making meatballs for example) only to have her wake up 1/2 hour later just for a hug then back off to sleep. If I can't get to her she gets out of bed and comes to find me.
If they are both napping in cribs, I would worry about the toddler climbing out. When we tried CIO my daughter climbed out of the crib at just under 18 months old. Once they are up they can be very very determined.
Perhaps there is a neighbor with a teen who might want to wake up early and baby sit while you are out running?
Good luck
(P.S> I hate to says this, but it is reality - if you do choose to go running with your husband, watch out for nosy neighbors, they might think you are endangering your children by leaving them unattended and call the ploice.)