H.D.
LOL! 2 hours? Seriously? I thought you were going to say like 1000 miles or 3000. =) I would do ANYTHING to have most of my family within two hours drive. =( I have lived in Germany and flown to Portland, Oregon for the holidays (once with a 3 and 1 year old traveling by myself, OY!). Chicago to Portland, SF to Portland, etc because we have lived all over (prior military). This Thanksgiving I was thrilled to have 7 out of 8 of our children here for the holidays (plus 3 others), 5 children live out of state. Believe me, when your parents pass away or your kids live 2000 miles away you will wonder why you thought 2 hours was that big a deal. THAT being said...
Make sure you are packed ahead of time, get the babies in bed at a decent hour (you too), try to get a room to stay in that will accomidate you and your children (even if you have to rent a hotel). Make sure you have toys for them to play with, things to eat and drink. Drive at night if you can, hopefully they will sleep in the car.
Try to remember two things; holidays only happen a few times a year and your children will only be babies so long. Let your elders bounce the babies on their knees (go take a nap while they do!) and take lots of pictures. In future years you won't remember the bother of traveling, what you will remember are the smiles, good food and the love of family.