I am currently working in HR and I can tell you there are a lot of people looking for jobs. For every job I post I receive at least 300 resumes. There is a lot of competition out there.
The biggest thing is to probably have someone look at your resume and see if you can make some improvements to make it stand it out. If you are applying through a job board like career builder or Monster it is better to attach your resume as a word document then to send your resume you created on their website because it will stand out a bit more and the person reading the resume will take a break from just scanning to looking at the resume.
If you can it would be beneficial to also fax your resume in addition to e-mail. Calling the company can actually backfire on you. Most companies get bombarded with phone calls and just don't have enough manpower to handle all the calls. It also gets annoying and if you don't know anything about the company or the job and you call it could count you out right away.
Good Luck and I hope you are able to find something.