I used simethicone with our first baby's occasional gas, and it worked great for her. But our second baby is way more gassy, and the simethicone didn't seem to do ANYTHING for her. The gripe water doesn't completely get rid of her gas, but it definitely makes her more comfortable. I don't know whether it would work for reflux specifically, but it couldn't hurt. Actually, for reflux the probiotics might work better. I had to take antibiotics when our youngest was about a month old, and they tore her system up. She had really bad gas and diarrhea. I had to do something for her, so i broke open an acidophilus caplet and poured a little on her tongue several times a day. It worked really well, and pretty quickly. They're actually not herbal at all, but the gripe water is. The probiotics are just capsules full of the same active bacteria cultures that are found in most yogurt. It's the reason why Dr.s tell you to eat yogurt when you have yeast infections or diarrhea. It might be worth it to read up on them, because they might be a good safe, natural choice. Hope this helped :)