B.D.
I've never heard of it being prescribed for acid reflux. I've always thought priobiotics (Align) were more for bowel health because your digestive flora is off.
I have taken it and it marginally improved my problem but it took the entire 7 week box to notice a difference.
It can also be expensive so if you have a Sam's or Costco membership you may want to buy it there.
If your 3 meds are not working than why have they not considered surgery?