TOTAllY!
Mine still travels 4 to 5 days a week, but when they were little I was always mad at him..... then I told him to stop calling me and telling me about his dinners and stuff. There's a lot that is not fun about traveling, but when you're eating PB&J with one hand and feeding the baby with the other it doesn't really matter how hard it is for him!
The other part is that when he came home, I wanted to go out... with him... and he wanted to stay home. Bummer.
So I started doing things on my own during the week (and I do work full-time but I telecommute, so no interaction like an office)... But I joined a bunco group and played one night a month, and paid for a sitter. I joined a book club, I would "do dinner" with girl friends once a month. So just about every week I had one night out... and paid a sitter, till they were old enough to be left alone for a few hours. It helped.
I still don't want to here about him finding the best Thai restaurant in Missouri or whatever, but it's bareable.