GOD YES!
Something with what ever they use for absorbing and the weaver.
All three of my boys had horrible rashes ANYTIME I used Pampers.
Huggies are the only diapers that are name brand I can use on my youngest(the only one left in diapers).
The Target Brand diapers are the other one I found that dont bother his hiney.
Mine all did ok with pampers until we had similar issues...With the first two I had to do the process of elimination....I just knew with the third and stopped using them...(my MIL bought diapers for me most the time..and she would only buy pampers...when I told her I needed to switch Zephyr to huggies she said sorry I wont buy then for you then)...
Its worth a try. Buy one of the smaller packages...which seems like a no brainer now that I have typed it!
I hope things clear up for her:)