J.S.
M., I too take Cymbalta, and the side effects for me are also drowsiness and (ugh - constipation)....so - I have found it most effective to take it right before bedtime. I know that this is safe, because my doctor knows that is what I do. Check with your own doctor, however, if you are on other medications. For example, I take Cymbalta, birth control and a bladder control medicine at bedtime, but take my thyroid medication all be itself in the a.m. Children do such wonderful things to our body, don't they? haha! In all seriousness, my throid medication has to be taken alone to work properly, and chances are, if you have other medicines, they have certain specifications too. Oh, by the way - I completely get the irritable part - after being on it for a year, I needed an adjustment because I felt totally irritable, out of focus, and anxious all the time. Turns out, it was from the medication not being at the right dosage for me. It was upped, and now I am back to my "old self". I really hope this helps you, and wish you good luck!