Q Benedryl May 25, 2007 by Rachel P. - Magnolia, MS Has any other moms taken benedryl throughout their pregnancies? If so did it cause any problems with the baby? ANSWERS See all 13 Hey R., Benedryl won't hurt the baby. When I was pregnat with my twins I had trouble sleeping. My doctor told me to take tylenol pm, which has benedryl in it, to h... http://women.webmd.com/Women-Medical-Reference/pregnancy-taking-medicine