A.B.
For just a weekend, I'd say definitely take a ferry, maybe out to Tilicum Village, if not for the show, for a stroll around and the boat ride is a nice short one. Any ferry you take to hike and picnic around any of the islands is a super fun day trip.
Pike's Place Market is a must, and touring the waterfront would be easy and fun. The sights, sounds and smells can't be beat.
Woodland Park zoo is wonderful, and The Discovery Museum is a lot of fun for little one's too!
http://www.wsdot.wa.gov/ferries/
http://www.pikeplacemarket.org/
http://www.zoo.org/
http://thechildrensmuseum.org/