My son's doctor had us sit on the floor and lay our son in between our legs so that his head is at your crotch and his arms are under your legs. This works GREAT! That way you are not over the top of him with your weight and there are no chances of squishing him or making it hard for him to breathe. Once you have him in this position, YOU are in control!! He can not move his head because your legs are holding it, and he can't move his arms because your legs are holding them down. He can kick his legs, but that's it and doesn't make a difference when giving him medication. With him in this position, place one finger in his mouth by his cheek and give the medication. He WILL swallow it and can't push it out or turn his head. He may cry when you get him in this position, but it's quick and doesn't hurt... he just doesn't like that he's not in control. After you let him up, give him a big hug and kiss. When he gets used to this method, give him the OPTION to take the medication OR you'll lay him down and do it the other way. My little boy learned pretty quick and he will just take the medication, but every once in awhile he'll fight it and we'll resort back to this method. Good Luck!