I feel for you--this is hard because you really want to go on vacation, and need to have that time with your husband, but it's heart-wrenching to leave your little one! We just left our 3 year-old with my parents for a trip to Mexico, and it was exactly the same--we were so excited at the time we booked it, and then when the day approached, I was a nervous wreck. You have the advantage of your child knowing her grandparents very well, which is a huge plus. I had only taken my son once before for a long weekend, because my folks live 2 hours away, so you are lucky that she has this relationship with them. Even though this is sort of a crazy way to think of it, I try to think of who my child would bond with if anything were to happen to me and my husband. And your daughter is lucky to be so close to your parents--if anything happened to you, she is already very bonded to them. So this trip will only strengthen that bond, and when you return, she will be even more bonded to you due to the separation. A few things that helped me do this, were that I called every day (if I were you I would call in the morning--I called in the afternoon and my mom said he had a harder time dealing with it then because he was tired from the day). Ask your mom to decide whether or not you should speak with your daughter--she will know if your daugther will be up for it or not. I really needed to hear my son's voice, but it may not have been the best thing for him every day. Your daughter is younger, which I think is actually easier because they are less aware--she will love being at your parents', and she will only notice you have been gone when you get back! I would also put some new toys/videos in her bag so grandma can have a few surprises in case she does get sad or anxious. Above all--don't worry--everything will be fine, and it will be REALLY good for you to relax and let go and bond with hubby. You can even sleep in and order room service!!!! Have a great trip, and remember, time passes, and you will be back home soon!