M.S.
Home depot has those inexpensive motion detectors for doors that beep if the door is opened. You can also place one in the doorway of her room, as leaving the house is not the only danger - she could turn on the stove or countless other things. Also, a baby gate in her bedroom doorway - she may not be able to get over it.
You can also try the child proof knob covers, she may not be able to maneuver that while sleeping.
Since you are up with worry, you can monitor how those things work, or need to be tweaked.
Blessings!