Yeah.. we have had our GSD since she was a puppy. And she is our only pet. So, when we travel, we have someone come to our home to pet sit.
We used to kennel her (we started when she was a puppy, so it wasn't something weird for her, and she was fine with crates... even though once she was not a little puppy anymore she wasn't in a crate, but in an indoor/outdoor run, due to size), but it was irregular. And the older she got, the less well she tolerated it. Finally, the place we had used to board her went out of business.
She tends to become depressed and not eat. She always lost weight when we boarded her. We tried one other boarding option, but it didn't really work out very well. She actually pulled the (super sized) crate wires apart with her mouth/teeth. She wanted out to go find us and/or people. She likes people, not other dogs. Sometimes I wonder if she knows she is even a dog!
We were fortunate that a trustworthy young teen moved in in our neighborhood shortly after that. She babysat our kids a few times while we went out to eat or the movies or whatever... and our dog loved her (and she loved our dog, too). So, she began pet sitting for us when we went on vacation.
Then she graduated and left for college. So, we engaged her younger brother for a while (who's now himself a senior in high school) in the same capacity. The last time we needed a pet sitter was on spring break, and he was also going to be out of town at the same time.
So,another teen neighbor (one of our son's friends) was propositioned. He was fine, she was fine.
I strongly recommend you check with some young neighbors that you sense a sense of responsibility about, and see what you can work out. Now when we are gone, we get pics and texts of our dog, regular updates, and when we get home we don't have to trek to the kennel to retrieve her. AND, we don't have to worry that our return date will fall on a day that the kennel closes before we get home, meaning she would be left to "suffer" there without us for another night, that we'd be paying for.
She's already home! She greets us when we open the door. :D
Our dog just turned 10. I leave all the vet information printed out, along with our contact information--just like I would for a babysitter for my kids. Age, approx weight, her vet's name/phone numbers and address, her medications, instructions for feeding, where her toys/leash are located, any rules or special "phrases" that are needed (the go potty command for example), etc.
I go over everything verbally, but don't expect them to remember all the details, so I put it in print so they can refer to it as needed, and always am available to call or text with any question at all.
Only one time was there a concern that she seemed a little depressed (and this from teen boy who just adores her and all dogs/puppies, so is particularly sensitive to her)... and so he spent some extra time hanging out here in the house watching TV to "be around" her.
Good luck.
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After your SWH information, I think I would check into some serious behavioral training for her, from a professional. So that you have some idea of what I am talking about, you should watch a few episodes of Cesar Milan, The Dog Whisperer. He often has clients who have nervous/anxious dogs, and helps them work to eliminate the problem. You dog should not be a nervous wreck because you step out of the room. And she can learn to be okay when you grab your purse to leave the house, too.
It isn't healthy for her to feel this way. There are methods to help train her NOT to be!
My dog also knows exactly what is about to happen (not just leaving the house, or going on vacation, but if we are going to swim in the pool, too--she knows the difference between underwear and a swimsuit!). I use verbal cues when I am leaving the house, so even without her noticing me getting my purse or putting on shoes (which she does notice these things and knows I am going outside or off in the car).. I TELL her "I'll be back after a while. Watch the house." I've said it since she was a puppy and to her it means "you will be alone in the house for a few hours. Then we'll come back." Because that is what happens each time I say that phrase.
It is wonderful that you have taken in a dog with high emotional/anxiety needs. Please look into some behavioral training for her so she can enjoy her life much better.