Looks like you have some great suggestions already but here is my two cents:
Organizing meals - I started using the Once A Month Cooking method when my husband deployed and I was home with a three month old and a perpetually hungry pre-teen. There are several sites you can use to do this, recipezaar.com, busycooks.about.com,etc. I even used my favorite weight watchers recipes - and YES! You can do this for a week at a time. The trick is to invest in two things: 1. A Foodsaver (I tried other containers, freezer bags with not so great results. Get the foodsaver if you plan to do this more than a week at a time) and 2. Invest the time to plan.
My plan is something like this:
1. Wednesday, check the store sales fliers for the great deals to stock up on. When cooking in bulk you can buy in bulk and save more (so you get the bonus of organizing your finances too :-))
2. I try to buy my groceries on Thursday or early on Friday to ensure there is a good selection and I am not using up my whole weekend for this.
3. Saturday after breakfast, I do the prep (cut, dice, measure, etc), I put a roast in the crock. Then after I feed the family lunch, I start cooking...I put chicken in the oven to roast, some on the grill, I brown ground meat, I even make up a batch of weight watchers vegetable soup for the week. You can do this prep for your breakfasts and lunches too, we just tend to be cereal and fruit people for breakfast but you can bake egg scrambles in muffin cups, flash freeze french toast, pancakes, etc for the week too.
As stuff finishes cooking, start dividing it - I will take some ground meat and portion it for spaghetti sauce, and some I will use for tacos or stroganoff. The roast is divided, some for dinner that night or Sunday lunch, the rest can be sliced for sandwiches, cubed for stew, you get the idea right? You can customize it for your family and your taste. Even vegetarians can do this.
As for organizing toys, put the kids to work... instead of demanding perfection, give them totes and baskets to group things in. My five year old has it down, art supplies on this shelf, stuffed animals here, dolls here, etc. Make it a fun game for them if you need to, bribe them at first if you need to, but have them do this work and you will be pleasantly surprised at how good they get about it. Also, as others told you, do a sanity check with your kids at least once a year - get rid of broken toys, donate toys that they don't play with... I involve my kids with this too - they know every year before Christmas that we go through our house and find things that we feel are worth giving to those in need. This makes it more real to them than just giving to toys for tots or sending money. They imagine someone else enjoying something of theirs and they are glad to give. Again, kids can really surprise you if you let them make some decisions about it.
Clothes, same applies - we are fairly strict about the 6 month rule in my house. If you haven't used it in 6 months and are pretty sure you won't use it in 6 months, out the house it goes. Obviously there are exceptions, but it helps. If you are crafty (which I am not) you can recycle clothes, but we usually donate, turn into rags or toss. The clothes you keep, I organize in categories, dresses together, then skirts, then pants, etc - some might think it is too much but trust me, taking the few extra minutes to do this when putting the laundry away saves so much time during the week! My husband is a big believer about putting your clothes out the night before too.
best of luck to you! Sorry this was so long.