L.H.
Hi Leslie,
I guess it all depends on how well you know this person and how comfortable you are around her. I wouldn't confront her with her issue, but if you're okay with it, you might consider telling her that she seems to be having some tough days lately and whether there is anything you can do to help her out. If she wants to discuss her menopause at that time, then it's up to her. I'd also let her know that you'd be there for her if, at any time, she feels like she might need someone to talk to or a listening ear.
She's lucky to have such a thoughtful friend like you. Hopefully, you will be able to get through this together.
Good luck,
L.