M.H.
My husband collects Hilton points so when we've been there we stayed at a Hampton Inn near the downtown market area and an Embassy Suites within walking distance of many sights/attractions. However, I think of both of them as more appropriate locations for walking in the city, not driving. How long are you stopping in Charleston? When my brother and SIL visited they stayed in a hotel in nearby Mt. Pleasant and then took a ferry/water taxi to the city.