A.G.
In Santa Fe there is a place called Museum Hill...totally worth checking out, they have an awesome childrens museum. If you go to santa fe, avoid the weekend of the 20-21st. It is Indian Market which is the tourist weekend and prices on everything go thru the roof! If you like senic drives, take the Enchanted Circle. Its very cool.
I would also suggest not staying downtown, stay on the southside, many of the hotels have free shuttles downtown and it will cost you half as much.
I dont know how far Durango, CO is from your area but there is a lot of stuff that is family friendly there and it is much cooler than 110 there for sure!