Most schools have an 'early drop off' program (in our area it starts at 6am) and afterschool care (in our area goes to 6pm).
In addition there are before and afterschool programs (like YMCA, Community Centers, church based, and private) that you drop the kids off in the morning and they bus the kids to the school in the morning, and bus the kids to the program in the afternoon. The program teachers are the ones who are responsible to hand off and to pick up while the parents work.
A good starting place would be your childrens' school... since the office will know both the school's own programs as well as which POPULAR private programs provide transportation to and from the school.
Nightwork is another good option... you sleep while the kids are in school (of course, getting the sick call from the nurse is problematic, but sick kids are problematic, period!). Many night shift workers I know STILL use either beforeschool programs (come home, get the kids up and fed and dropped off at the early program and go to bed, then pick up yourself afterschool, or vice versa, kids up and fed and dropped off, then the afterschool program so you never have to worry about oversleeping).
These programs range a LOT in cost. YMCA, for example, is free to almost free IF AND ONLY IF you qualify. If you don't qualify (in our area!!! prices are different in every area!!!), in our area it's $100 a month membership fee, and $800 per month for the before and afterschool program PER kid (300 mornings, 500 afternoons), plus $50 per half day (early dismissals, parent teacher conferences, etc.), and $100 per full day for no-school-days.
MYSELF... I'd go talk to the school, find out what programs are available, look into fees, and then go start looking for work. Why? Because it really changes what kinds of jobs you can afford to work. The care is there, but wages and hours are important to know, so you can subtract the hours in your mind (to find out what you'll 'actually' be making after childcare costs AND to know what programs you qualify for reduced fees. An extra $500 a month is a job to NOT get if it bumps you over the income level, and makes you lose $300 a month ($800 in childcare).