We have two - our oldest will be 5 in October, and our youngest will be 2 in November, and we're 42 (or at least DH will be in November).
We had to go through IVF for #1, and debated long and hard about whether or not to "go for two" knowing that we'd have to go through another fertility cycle. Plus, our first was a twin until about 10 weeks into the pregnancy when we lost her twin. We decided to try just once more, and she's now 22 months, and the biggest daddy's girl you ever saw.
I have to say I was more ready to try for #2 than DH was - he just was unsure about it. But hasn't regretted it at all. She won't even come to me in the middle of the night - it HAS to be him. She even looks more like him than she does me.
I've teased about having a third, and my sister just had #3 (she has two other daughters = 6 + 4). She said #3 is an angel. She rarely cries - just eats, sleeps and poops.
It's changed our lives a lot having our daughters around. We laugh a lot more. They love to play. We look at things a lot differently than we used to...what we watch on tv, what we listen to, etc. Not that we've dramatically altered that stuff - just we're cautious of.
But we look at going to the park or places where the kids can play. We might take a 1/2 day off from work so that DH and I can go to dinner alone and do any shopping or anything we need to do so that when we pick up the girls from the sitter we can devote the time to playing with them.