J.B.
After 5 years of this I'd be seeing a naturopath in addition to the conventional doctors. I'd want to know *why* she has reflux. Have they offered a root cause? Allergy, lactose intolerance, gluten sensitivity? Have you tried an elimination diet to see what her triggers are? Does she need probiotics or digestive enzymes?
It's not normal for the digestive system to not work - rather than treat the symptoms, which is really all the conventional medicine does, I would also be working on correcting whatever is causing the reflux - either she's having an inflammatory response to something or is deficient in something. You can treat the symptoms while searching for a root cause - she doesn't need to suffer while you try to figure things out, but a naturopath can guide you in the figure-it-out process so you're not trying things that aren't helpful and won't yield good information.
The more I learn about overall health, the more I see that the digestive tract is the key to health. Our immune systems, hormones, and even things like mood all start in the gut so it's incredibly important to get it working as naturally as possible. Things like Zantac can be tremendously helpful in alleviating immediate symptoms - I took it when I had pregnancy-induced heartburn - but often what someone with stomach issues needs is, ironically, more stomach acid. Shutting off the stomach acid can really f-up the digestive cycle if used long term. Read up on hydrochloric acid as a treatment for reflux - the thought is that with *more* acid in the stomach, the stomach can digest food more quickly and efficiently, thereby keeping everything moving. When the stomach doesn't produce enough acid and digest food quickly enough, food sits in the stomach and that's when the muscle that keeps the stomach and esophagus separate can be stressed and leak stomach acid up into the esophagus.
Good luck - I hope you get some answers and get her digestive tract on track soon.