My advise is have a small stroller you can use through out the airport, when you go to get on the plane at the gate right before you actually step onto the plane they will take your stroller and checkit below, when you land at your designated city and get off the plane it will be ready and waiting for you as your getting off the plane. Wheelchairs and strollers that are checked like that are the first things pulled off the plane.
Have all your necessitys in a diaper bag but don't have to many bags, purses etc., it's just to much to keep track of. I usually carry a big nice backpack have all of my daughter's junk and my wallet, plane tix go in there as well I leave the purse at home or put it in my baggage. Make sure you have enough diapers, food incase your plane was to be delayed or you get stranded.
When we flew to family they had a package of diapers waiting for us at the house so I wouldn't have to haul a package with, I took enough for the plane ride and a few extra just in case. They also would buy my daughter any special food, babyfood, crackers she would need at their house so once again I wasn't dragging so much with us.
The waiting carseat is a really smart choice, it's so hard to haul that through a airport.
Change your son's diaper at the last minute before you get on the plane right before they start boarding and hopefully you'll not need to on the plane because that's a hard one to do on the plane. When your sitting at the airport waiting to board the plane you might want to let him get his wiggles out, at 10mos. let him crawl around or just not be restrained. I let my daughter run around and get pooped out and we choose to board last they always say anyone needing extra assistance or traveling with small children can board first but that just means my daughter has to sit on the plane that much longer so I wait and board last.
Then make sure you have a pacifier,bottle, something for him to suck on during take off and landing. My daughter(6) has flown over 10x and has never complained her ears hurt I always gave her a sippy cup, gum or whatever though.
The only problem I had with her as a lap baby flying was when she fell asleep she was laying longways and her feet or legs were always sticking out in the aisle or in the person's way next to us. So you might have to have him fall asleep over your shoulder. I also had a problem with my daughter on my lap and then the jerk in front of me reclined his seat and nearly squished my daughter so I got the flight attendants attention and she moved us to another seat.
To change a diaper on the plane I had her stand on the toliet with the lid down and changed her standing up. It was hard and not how we normally do it but it worked.
Good luck and enjoy your Thanksgiving with your family.