Hi M. - As someone who has been there with colic, it definitely could be colic that your little one is going through. The "rule of three's" applies with colic and did with my youngest - starts around 3 weeks, crying for 3 or more hours a day, and lasting until 3 months old (though mine went for the bonus version of 4+ months!!). It is usually related to digestion/food issues, though not always, and from your other post is sounds as if that could be the case as well. My youngest would start crying around 4-5 pm, and would seriously not stop entirely until 10 or 11 pm sometimes. Then after her middle of the night feeding, she'd often cry some more and be unable to get back to sleep, no matter what we did. She always had trouble getting to sleep without a little help. This being said, it is common for babies to fuss around dinnertime and not respond to comforting. It is exhausting for parents because you are tired from the day and you have to walk the baby around the house for hours! I understand and have been there. You have a lot happening at once because you are also working on weaning her, so the fussiness could also be related to that. I'd have your husband give her a bottle since she'll associate you and your smell with nursing, and see if that helps a little. Other than that, I would not have survived without the baby carrier during these fussy times, since my daughter seemed to just want to be against one of us and near us. Try wearing her as best you can during the fussy times, then experiment with putting her down once in a while to see if she can get to sleep or be more content after being near you.
Lastly, the one thing that did help a little in my situation was to see a chiropractor who worked with babies and kids. It turned out that my daughter had a lot of digestive backup and the adjustments helped get everything moving so to speak! It got us over the hump a little. Good luck - I know what you are going through!