Absolutely! Now my marriage is far from perfect, but our different religions have not been the problem at all. He is Jewish and I am Catholic. Raising my children as Catholic was a deal-breaker for me, so he agreed to that before we even started dating seriously. But although our children are being raised Catholic (including weekly Mass, religious education, and receiving sacraments) I am very respectful towards and embracing of their Jewish heritage. We celebrate all of the holidays, and my kids go to a memorial service at a temple once a year. If my husband were active in his faith and if we were members of a temple, we would worship there on a regular basis and go to high holidays, but my husband doesn't really practice his religion. I think that's too bad, because I think that he misses out by not having a spiritual anchor in his life and I truly love the beauty and simplicity of Friday night services. I also wish that we went more often so that the children could learn the prayers and recite some Hebrew. I do worry that the traditions in his family will die off in another generation because none of his generation really do much to keep things alive, but hopefully as we get older they'll all take more ownership of hosting Hanukkah and Passover Seder instead of relying on Nana and various Aunts to handle that. Oddly, I am in charge of Passover desserts and made a brisket last year that got rave reviews lol!
I think that as long as the questions regarding things like how will the children be raised, which holidays will we celebrate, how will we explain the differences to the children, can we be truly respectful of one another's beliefs, etc. are settled before marriage or very early on, things will be OK. I always think it's a little sad when parents disagree so they don't raise the children in any religion - to each their own, but it seems a shame that when there are two belief systems in place a child may grow up with nothing instead of one or both.
I will add a couple of things - we were married in a combined Catholic/Jewish ceremony with a priest and a rabbi in a non-denominational chapel. My marriage is recorded in the Church but it is not sacramental. I think that both of our families really appreciated that we went to great lengths to honor and legitimately represent both religions at our wedding. My in-laws a phenomenally accepting and were at the baptism of our children, so we don't have to deal with pressure from our families.
The only negative is that I do feel a longing when I am at Mass to be there truly as a family. I see families together and something feels like it's missing, but that's the choice I made. My husband will not go to a Catholic church unless it's for a very good reason (sacraments). I also temper my Christmas decor and use my garden club and church decorating as an outlet for my urge to go Christmas-decor crazy. Oddly, he met a female pastor of a Christian church last year (she is a counselor) and he has been really drawn to that congregation and goes to services there sometimes. I never would have expected him to find a spiritual connection to a Protestant church, but God works in mysterious ways and as long as he gets something out of it, I encourage him.