I think any time extensive use of medication is involved in your children's life it can be unsettling. Have you tried consulting with a psychologist to go over all options available? Also, there are quite a bit of informative websites online.
I know someone who was diagnosed with ADHD as an adult and wishes that he had been diagnosed as a child so that he could possibly have avoided a lot of difficulties growing up. He had difficulties with school and peers, relationships, jobs and social aspects. He now takes medication and has noticed a significant improvement in his abililty to slow down and focus.
I am sure, as with everything, there are varying degrees of this condition and what works for some may not work for all. I think the best thing anyone can do is research the subject and consult with medical doctors and psychologists and together come up with a solution that works best for the person involved.
I wish you the best.