I would say the Ford, mostly because the Sequoia gets terrible, and I mean terrible gas mileage! The Expeditions are pretty roomy and they drive like an SUV, which is normal for an SUV!!! If you want a big vehicle it is going to drive like a big vehicle. Personally neither have any more room cargo wise than a van, and front wheel drive works great for us in the snow, so we decided to get a van instead, but if I was going to go for an SUV just because of it, I would get an Expedition, I loved my Explorer, so to me the obvious choice is the Expedition. Oh and the obvious difference is $$$!